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Albendazole did not detrimentally affect female or male fertility in the rat at an oral dosage of 30 mg/kg/day (0.32 times the suggested human dosage based on body surface area in mg/m2).





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Albendazole has actually been revealed to be teratogenic (to trigger embryotoxicity as well as skeletal malformations) in expectant rats and also bunnies. The teratogenic reaction in the rat was shown at oral dosages of 10 and 30 mg/kg/day (0.10 times and also 0.32 times the suggested human dosage based on body area in mg/m2, specifically) during pregnancy days 6 to 15 as well as in pregnant bunnies at dental doses of 30 mg/kg/day (0.60 times the advised human dose based upon body area in mg/m2) provided throughout gestation days 7 to 19. In the rabbit research, parental toxicity (33 % death) was noted at 30 mg/kg/day. In computer mice, no teratogenic impacts were noted at oral dosages up to 30 mg/kg/day (0.16 times the recommended human dose based on physical body area in mg/m2), carried out during gestation days 6 to 15. There are no sufficient and also well-controlled research studies of albendazole management in expectant women. Albendazole needs to be made use of while pregnant simply if the potential benefit justifies the prospective risk to the fetus (see WARNINGS).

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